U2AF1L4
Gene Information
- Official Symbol: U2AF1L4
- Official Name: U2 small nuclear RNA auxiliary factor 1 like 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 199746
- UniProt: Q8WU68
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity). {ECO:0000250|UniProtKB:Q8BGJ9}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4553
- Expression level (log2 read counts): 3.92
U2AF1L4 Expression in NALM6 Cells: 3.92
