UniProt Summary: Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein. {ECO:0000269|PubMed:16254333, ECO:0000269|PubMed:20133869}.
Pfam DomainsGO Terms
Pfam Domains
UBA e1 C
UBA e1 thiolCys
ThiF
UBACT
GO Terms
ISG15 activating enzyme activity
ISG15-protein conjugation
negative regulation of type I interferon production
regulation of type I interferon production
ubiquitin-protein transferase activity
negative regulation of cytokine production
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
regulation of cytokine production
protein modification by small protein conjugation
cellular response to DNA damage stimulus
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal
macromolecule catabolic process
organonitrogen compound catabolic process
negative regulation of multicellular organismal process
proteolysis
ATP binding
cellular response to stress
organic substance catabolic process
cellular catabolic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)