Pfam Domains GO Terms
| His Phos 1 |
| collagen-activated tyrosine kinase receptor signaling pathway |
| negative regulation of platelet aggregation |
| collagen-activated signaling pathway |
| negative regulation of bone resorption |
| negative regulation of homotypic cell-cell adhesion |
| negative regulation of bone remodeling |
| regulation of platelet aggregation |
| negative regulation of platelet activation |
| negative regulation of tissue remodeling |
| regulation of homotypic cell-cell adhesion |
| negative regulation of osteoclast differentiation |
| regulation of platelet activation |
| phosphoprotein binding |
| regulation of bone resorption |
| platelet aggregation |
| negative regulation of myeloid leukocyte differentiation |
| phosphatase activity |
| regulation of bone remodeling |
| negative regulation of blood coagulation |
| negative regulation of hemostasis |
| negative regulation of coagulation |
| homotypic cell-cell adhesion |
| regulation of osteoclast differentiation |
| negative regulation of wound healing |
| regulation of tissue remodeling |
| negative regulation of myeloid cell differentiation |
| regulation of release of sequestered calcium ion into cytosol |
| regulation of blood coagulation |
| regulation of hemostasis |
| regulation of coagulation |
| negative regulation of response to wounding |
| regulation of calcium ion transport into cytosol |
| protein tyrosine phosphatase activity |
| negative regulation of leukocyte differentiation |
| peptidyl-tyrosine dephosphorylation |
| regulation of myeloid leukocyte differentiation |
| regulation of sequestering of calcium ion |
| negative regulation of hemopoiesis |
| platelet activation |
| regulation of wound healing |
| regulation of calcium ion transmembrane transport |
| regulation of response to wounding |
| negative regulation of cell-cell adhesion |
| negative regulation of cell activation |
| protein dephosphorylation |
| regulation of protein binding |
| negative regulation of protein kinase activity |
| regulation of myeloid cell differentiation |
| negative regulation of kinase activity |
| regulation of calcium ion transport |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| negative regulation of transferase activity |
| ubiquitin protein ligase binding |
| blood coagulation |
| coagulation |
| hemostasis |
| dephosphorylation |
| regulation of cation transmembrane transport |
| negative regulation of response to external stimulus |
| regulation of binding |
| regulation of metal ion transport |
| regulation of cell-cell adhesion |
| negative regulation of protein phosphorylation |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| regulation of hemopoiesis |
| regulation of ion transmembrane transport |
| wound healing |
| regulation of body fluid levels |
| cell-cell adhesion |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| response to wounding |
| negative regulation of protein modification process |
| regulation of cell activation |
| regulation of cell adhesion |
| regulation of ion transport |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of kinase activity |
| regulation of cellular localization |
| cell adhesion |
| biological adhesion |
| negative regulation of developmental process |
| regulation of transferase activity |
| negative regulation of cellular protein metabolic process |
| identical protein binding |
| cell activation |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| regulation of transport |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Nifuroxazide 1μM R01 exp51 | -2.09 |
| Nicotinamide 2000μM R01 exp50 | -1.75 |
| 39°C R06 exp303 | -1.72 |
| INK128 0.2μM R02 exp70 | 1.71 |
| Dorsomorphin 5μM R07 exp357 | 1.79 |
| LY2090314 0.003μM R08 exp500 no dilution day6 | 2.32 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution