UNC5D
Gene Information
- Official Symbol: UNC5D
- Official Name: unc-5 netrin receptor D
- Aliases and Previous Symbols: N/A
- Entrez ID: 137970
- UniProt: Q6UXZ4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity). {ECO:0000250|UniProtKB:Q8K1S2, ECO:0000305|PubMed:24519068, ECO:0000305|PubMed:24691657}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3455
- Expression level (log2 read counts): -1.85
UNC5D Expression in NALM6 Cells: -1.85
