Pfam Domains GO Terms
| UBA |
| Chorein N |
| DUF1162 |
| protein retention in Golgi apparatus |
| positive regulation of mitophagy |
| regulation of mitophagy |
| positive regulation of autophagy of mitochondrion |
| protein localization to Golgi apparatus |
| protein targeting to vacuole |
| regulation of autophagy of mitochondrion |
| establishment of protein localization to vacuole |
| protein localization to vacuole |
| extrinsic component of membrane |
| positive regulation of macroautophagy |
| maintenance of protein location in cell |
| cell |
| maintenance of location in cell |
| maintenance of protein location |
| positive regulation of mitochondrion organization |
| positive regulation of autophagy |
| vacuolar transport |
| maintenance of location |
| regulation of macroautophagy |
| regulation of mitochondrion organization |
| regulation of autophagy |
| protein targeting |
| positive regulation of cellular catabolic process |
| establishment of protein localization to organelle |
| positive regulation of catabolic process |
| mitochondrion organization |
| positive regulation of organelle organization |
| protein localization to organelle |
| regulation of cellular catabolic process |
| regulation of catabolic process |
| intracellular protein transport |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| establishment of localization in cell |
| nitrogen compound transport |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| MS023 2μM R03 exp134 | -2.67 |
| Lapatinib 5μM R01 exp47 | -1.89 |
| Q15 1 to 2μM on day4 R04 exp164 | -1.72 |
| Disulfiram 4.3μM R06 exp281 | 1.93 |
| Q15 2.7μM R02 exp79 | 2.41 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 16/28 |
| blood | 11/28 |
| bone | 13/26 |
| breast | 20/33 |
| central nervous system | 36/56 |
| cervix | 1/4 |
| colorectal | 13/17 |
| esophagus | 7/13 |
| fibroblast | 0/1 |
| gastric | 10/16 |
| kidney | 14/21 |
| liver | 10/20 |
| lung | 47/75 |
| lymphocyte | 9/16 |
| ovary | 10/26 |
| pancreas | 16/24 |
| peripheral nervous system | 6/16 |
| plasma cell | 9/15 |
| prostate | 1/1 |
| skin | 17/24 |
| soft tissue | 4/9 |
| thyroid | 1/2 |
| upper aerodigestive | 14/22 |
| urinary tract | 15/29 |
| uterus | 3/5 |
Expression Distribution