YWHAG
Gene Information
- Official Symbol: YWHAG
- Official Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
- Aliases and Previous Symbols: N/A
- Entrez ID: 7532
- UniProt: P61981
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. {ECO:0000269|PubMed:16511572}.
Pfam Domains GO Terms
Pfam Domains
| 14-3-3 |
GO Terms
| protein kinase C inhibitor activity |
| insulin-like growth factor receptor binding |
| regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| protein kinase C binding |
| receptor tyrosine kinase binding |
| positive regulation of establishment of protein localization to mitochondrion |
| regulation of mitochondrial membrane permeability |
| regulation of establishment of protein localization to mitochondrion |
| regulation of membrane permeability |
| presynapse |
| ciliary basal body-plasma membrane docking |
| positive regulation of mitochondrion organization |
| positive regulation of protein localization to membrane |
| mitochondrial membrane organization |
| G2/M transition of mitotic cell cycle |
| negative regulation of protein serine/threonine kinase activity |
| cell cycle G2/M phase transition |
| cellular response to insulin stimulus |
| organelle localization by membrane tethering |
| positive regulation of apoptotic signaling pathway |
| membrane docking |
| regulation of mitochondrion organization |
| regulation of protein localization to membrane |
| regulation of synaptic plasticity |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of cell cycle G2/M phase transition |
| mitochondrial transport |
| negative regulation of protein kinase activity |
| response to insulin |
| protein domain specific binding |
| negative regulation of kinase activity |
| cellular response to peptide hormone stimulus |
| mitotic cell cycle phase transition |
| negative regulation of transferase activity |
| cell cycle phase transition |
| positive regulation of cellular protein localization |
| cellular response to peptide |
| cilium assembly |
| protein targeting |
| cilium organization |
| response to peptide hormone |
| regulation of apoptotic signaling pathway |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| focal adhesion |
| mitochondrion organization |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| negative regulation of phosphorylation |
| plasma membrane bounded cell projection assembly |
| regulation of cell cycle phase transition |
| cell projection assembly |
| positive regulation of establishment of protein localization |
| response to peptide |
| regulation of protein serine/threonine kinase activity |
| regulation of cellular protein localization |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| organelle localization |
| negative regulation of protein modification process |
| mitotic cell cycle process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of neuron differentiation |
| cellular response to nitrogen compound |
| mitotic cell cycle |
| positive regulation of cell death |
| regulation of establishment of protein localization |
| regulation of cell cycle process |
| organelle assembly |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of neurogenesis |
| membrane organization |
| regulation of kinase activity |
| response to hormone |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| regulation of transferase activity |
| positive regulation of transport |
| intracellular protein transport |
| cell cycle process |
| response to organonitrogen compound |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| identical protein binding |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| cell projection organization |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| mitochondrion |
| regulation of organelle organization |
| cell cycle |
| RNA binding |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| protein transport |
| intracellular transport |
| generation of neurons |
| peptide transport |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| neurogenesis |
| positive regulation of signal transduction |
| regulation of cell death |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of protein modification process |
| regulation of transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4411
- Expression level (log2 read counts): 8.46
Expression Distribution
YWHAG Expression in NALM6 Cells: 8.46
