ZCCHC12
Gene Information
- Official Symbol: ZCCHC12
- Official Name: zinc finger CCHC-type containing 12
- Aliases and Previous Symbols: N/A
- Entrez ID: 170261
- UniProt: Q6PEW1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a downstream effector of bone morphogenetic protein (BMP) signalling. This protein contains a zinc finger domain and functions as a transcriptional coactivator. Variation in this gene may be associated with X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
- UniProt Summary: Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13388
- Expression level (log2 read counts): -4.27
ZCCHC12 Expression in NALM6 Cells: -4.27
