Pfam Domains GO Terms
| regulation of DNA strand resection involved in replication fork processing |
| cerebellar molecular layer development |
| cerebellar molecular layer morphogenesis |
| dendrite arborization |
| neuron projection arborization |
| dendritic spine morphogenesis |
| positive regulation of oligodendrocyte differentiation |
| dendritic spine development |
| cerebellar cortex morphogenesis |
| dendritic spine organization |
| cerebellum morphogenesis |
| regulation of oligodendrocyte differentiation |
| neuron projection organization |
| hindbrain morphogenesis |
| positive regulation of glial cell differentiation |
| cerebellar cortex development |
| regulation of double-strand break repair via homologous recombination |
| regulation of DNA-dependent DNA replication |
| dendrite morphogenesis |
| regulation of glial cell differentiation |
| positive regulation of gliogenesis |
| regulation of double-strand break repair |
| postsynapse organization |
| telomere maintenance |
| telomere organization |
| dendrite development |
| cerebellum development |
| regulation of DNA recombination |
| regulation of DNA replication |
| metencephalon development |
| regulation of gliogenesis |
| regulation of DNA repair |
| hindbrain development |
| negative regulation of neuron projection development |
| microtubule organizing center |
| negative regulation of cell projection organization |
| regulation of response to DNA damage stimulus |
| negative regulation of neuron differentiation |
| synapse organization |
| negative regulation of neurogenesis |
| negative regulation of nervous system development |
| negative regulation of cell development |
| anatomical structure homeostasis |
| regulation of DNA metabolic process |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cell part morphogenesis |
| positive regulation of nervous system development |
| positive regulation of cell development |
| cell morphogenesis involved in differentiation |
| regulation of neuron differentiation |
| neuron projection development |
| intracellular membrane-bounded organelle |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| cell morphogenesis |
| regulation of cellular response to stress |
| brain development |
| DNA metabolic process |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| central nervous system development |
| neuron differentiation |
| chromosome organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of developmental process |
| regulation of response to stress |
| generation of neurons |
| neurogenesis |
| homeostatic process |
| cell development |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| HMS-I1 1μM R01 exp46 | -1.74 |
| Torin1 0.08μM R02 exp82 | 1.81 |
| RK-33 8μM R08 exp518 | 1.88 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution