ACOX2

Entrez Summary: The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe cognitive disability, and death in children. [provided by RefSeq, Mar 2009].
UniProt Summary: Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. {ECO:0000269|PubMed:27884763}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ACOX
Acyl-CoA dh M

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity
acyl-CoA oxidase activity
fatty acid beta-oxidation using acyl-CoA oxidase
positive regulation of response to oxidative stress
fatty acid binding
bile acid biosynthetic process
FAD binding
bile acid metabolic process
peroxisomal matrix
flavin adenine dinucleotide binding
fatty acid beta-oxidation
protein localization to peroxisome
protein targeting to peroxisome
establishment of protein localization to peroxisome
peroxisomal transport
fatty acid oxidation
lipid oxidation
peroxisome organization
regulation of response to oxidative stress
fatty acid catabolic process
peroxisome
monocarboxylic acid catabolic process
steroid biosynthetic process
lipid homeostasis
monocarboxylic acid biosynthetic process
organic hydroxy compound biosynthetic process
cellular lipid catabolic process
lipid modification
steroid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
lipid catabolic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
protein targeting
establishment of protein localization to organelle
small molecule catabolic process
organic hydroxy compound metabolic process
monocarboxylic acid metabolic process