AKR1C1

Entrez Summary: N/A
UniProt Summary: Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. {ECO:0000269|PubMed:11013348, ECO:0000269|PubMed:8573067}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM131593 0.1μM R01 exp58	-2.3
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-2.03
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-2
Pyronaridine 1μM R06 exp295	-1.85
Clomiphene 4.4μM R02 exp68	-1.76
Nocodazole 0.2μM R02 exp64	-1.73
ONC212 0.15μM R08 exp513	2.02

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

androsterone dehydrogenase (B-specific) activity
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
indanol dehydrogenase activity
phenanthrene 9,10-monooxygenase activity
response to jasmonic acid
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
cellular response to jasmonic acid stimulus
ketosteroid monooxygenase activity
bile acid binding
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
carboxylic acid binding
daunorubicin metabolic process
doxorubicin metabolic process
polyketide metabolic process
intestinal cholesterol absorption
steroid dehydrogenase activity
aminoglycoside antibiotic metabolic process
aldo-keto reductase (NADP) activity
intestinal lipid absorption
alcohol dehydrogenase (NADP+) activity
progesterone metabolic process
tertiary alcohol metabolic process
alditol:NADP+ 1-oxidoreductase activity
lipid digestion
retinal metabolic process
glycoside metabolic process
C21-steroid hormone metabolic process
bile acid and bile salt transport
quinone metabolic process
intestinal absorption
bile acid metabolic process
cellular aldehyde metabolic process
cholesterol transport
secondary metabolic process
sterol transport
cellular ketone metabolic process
digestive system process
primary alcohol metabolic process
cholesterol homeostasis
sterol homeostasis