ALOX5AP

Entrez Summary: This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].
UniProt Summary: Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO:0000269|PubMed:2300173, ECO:0000269|PubMed:8440384}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

leukotriene-C4 synthase activity
arachidonic acid binding
lipoxin biosynthetic process
lipoxin metabolic process
lipoxygenase pathway
leukotriene biosynthetic process
glutathione peroxidase activity
glutathione transferase activity
leukotriene metabolic process
protein homotrimerization
unsaturated fatty acid biosynthetic process
enzyme activator activity
icosanoid biosynthetic process
protein trimerization
cellular response to calcium ion
cellular oxidant detoxification
fatty acid derivative biosynthetic process
cellular detoxification
protein N-terminus binding
unsaturated fatty acid metabolic process
icosanoid metabolic process
fatty acid biosynthetic process
detoxification
response to calcium ion
fatty acid derivative metabolic process
nuclear envelope
monocarboxylic acid biosynthetic process
cellular response to metal ion
cellular response to toxic substance
cellular response to inorganic substance
nuclear membrane
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
protein homooligomerization
response to metal ion
response to toxic substance
protein complex oligomerization
monocarboxylic acid metabolic process
response to inorganic substance