ANXA6
Gene Information
- Official Symbol: ANXA6
- Official Name: annexin A6
- Aliases and Previous Symbols: N/A
- Entrez ID: 309
- UniProt: P08133
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
Pfam Domains GO Terms
Pfam Domains
| Annexin |
GO Terms
| chondroitin sulfate binding |
| plasma membrane repair |
| ligand-gated ion channel activity |
| growth plate cartilage chondrocyte differentiation |
| mitochondrial calcium ion homeostasis |
| chondrocyte differentiation involved in endochondral bone morphogenesis |
| growth plate cartilage development |
| endochondral bone growth |
| bone growth |
| cartilage development involved in endochondral bone morphogenesis |
| cholesterol binding |
| calcium channel activity |
| neural crest cell migration |
| calcium-dependent phospholipid binding |
| negative regulation of sequestering of calcium ion |
| phosphatidylserine binding |
| calcium-dependent protein binding |
| endochondral bone morphogenesis |
| neural crest cell development |
| chondrocyte differentiation |
| mesenchymal cell development |
| stem cell development |
| neural crest cell differentiation |
| plasma membrane organization |
| organ growth |
| melanosome |
| bone morphogenesis |
| late endosome membrane |
| regulation of sequestering of calcium ion |
| lipid binding |
| mesenchymal cell differentiation |
| stem cell differentiation |
| regulation of muscle contraction |
| ameboidal-type cell migration |
| cartilage development |
| calcium ion transmembrane transport |
| bone development |
| actin filament binding |
| mesenchyme development |
| connective tissue development |
| regulation of muscle system process |
| skeletal system morphogenesis |
| calcium ion transport |
| apoptotic signaling pathway |
| divalent metal ion transport |
| lysosomal membrane |
| divalent inorganic cation transport |
| protein homooligomerization |
| collagen-containing extracellular matrix |
| developmental growth |
| GTP binding |
| growth |
| focal adhesion |
| endomembrane system organization |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| cellular divalent inorganic cation homeostasis |
| wound healing |
| divalent inorganic cation homeostasis |
| skeletal system development |
| protein complex oligomerization |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| response to wounding |
| regulation of system process |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| perinuclear region of cytoplasm |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| cellular chemical homeostasis |
| ion homeostasis |
| cation transport |
| membrane organization |
| protein homodimerization activity |
| cellular homeostasis |
| apoptotic process |
| ion transmembrane transport |
| animal organ morphogenesis |
| cell migration |
| programmed cell death |
| cell motility |
| localization of cell |
| cell death |
| chemical homeostasis |
| mitochondrion |
| transmembrane transport |
| locomotion |
| ion transport |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| homeostatic process |
| cell development |
| tissue development |
| protein-containing complex subunit organization |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MS023 2μM R03 exp134 | 1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3795
- Expression level (log2 read counts): 5.61
Expression Distribution
ANXA6 Expression in NALM6 Cells: 5.61
