AP1M1

Entrez Summary: N/A
UniProt Summary: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

clathrin adaptor complex
endosome to melanosome transport
pigment granule maturation
endosome to pigment granule transport
pigment accumulation
cellular pigment accumulation
melanosome organization
pigment granule organization
regulation of defense response to virus by virus
pigment cell differentiation
developmental pigmentation
cellular pigmentation
clathrin-coated vesicle membrane
pigmentation
specific granule membrane
trans-Golgi network membrane
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
cytoplasmic vesicle membrane
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
antigen processing and presentation
developmental maturation
lysosomal membrane
vesicle organization
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
Golgi membrane
leukocyte activation involved in immune response
cell activation involved in immune response
viral process