ASB4

Entrez Summary: N/A
UniProt Summary: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Cul5-RING ubiquitin ligase complex
positive regulation of vasculogenesis
regulation of vasculogenesis
Cul2-RING ubiquitin ligase complex
protein autoubiquitination
positive regulation of vasculature development
ubiquitin protein ligase activity
ubiquitin-protein transferase activity
ubiquitin protein ligase binding
regulation of vasculature development
post-translational protein modification
protein ubiquitination
protein modification by small protein conjugation
positive regulation of cell differentiation
protein modification by small protein conjugation or removal
regulation of anatomical structure morphogenesis
positive regulation of developmental process
intracellular signal transduction
positive regulation of multicellular organismal process
regulation of cell differentiation