AUNIP

Entrez Summary: N/A
UniProt Summary: DNA-binding protein that accumulates at DNA double- strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non-homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670). {ECO:0000269|PubMed:20596670, ECO:0000269|PubMed:29042561}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	-2.04
Olaparib 4μM R08 exp512	-1.81
Taxol 0.002μM R01 exp54	1.98
Etoposide 0.1μM R05 exp198	2.06
Pifithrin-alpha 20μM R07 exp390	2.17
Isonicotinamide 500μM R03 exp129	2.27
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	2.58

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of double-strand break repair via nonhomologous end joining
site of DNA damage
regulation of double-strand break repair via nonhomologous end joining
negative regulation of double-strand break repair
negative regulation of DNA repair
damaged DNA binding
regulation of double-strand break repair
negative regulation of response to DNA damage stimulus
double-strand break repair via homologous recombination
recombinational repair
negative regulation of DNA metabolic process
spindle pole
regulation of DNA repair
spindle organization
double-strand break repair
regulation of response to DNA damage stimulus
DNA recombination
regulation of DNA metabolic process
microtubule cytoskeleton organization
centrosome
DNA repair
microtubule-based process
regulation of cellular response to stress
DNA metabolic process
cellular response to DNA damage stimulus
cell cycle process
cytoskeleton organization
cell cycle
negative regulation of nucleobase-containing compound metabolic process
regulation of response to stress
negative regulation of response to stimulus
cellular response to stress