BEST2

Entrez Summary: N/A
UniProt Summary: Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO:0000269|PubMed:11904445, ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Cyclosporin-A 0.8μM R07 exp347	1.7
Chlorpromazine 10μM R07 exp344	1.85

chloride channel complex
membrane depolarization
chloride channel activity
chloride transmembrane transport
chloride transport
inorganic anion transmembrane transport
inorganic anion transport
cilium
anion transmembrane transport
regulation of membrane potential
sensory perception of smell
sensory perception of chemical stimulus
anion transport
inorganic ion transmembrane transport
molecular function
ion transmembrane transport
sensory perception
transmembrane transport
ion transport
nervous system process
system process