BIRC8

Gene Information

Official Symbol: BIRC8
Official Name: baculoviral IAP repeat containing 8
Aliases and Previous Symbols: N/A
Entrez ID: 112401
UniProt: Q96P09
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Protects against apoptosis mediated by BAX.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15580
Expression level (log2 read counts): -2.43

Expression Distribution

Screen	Score
FK-506 5μM R07 exp358	1.74
Calcium Ionophore 0.4μM R07 exp342	1.8
NMS-873 0.07μM R07 exp380	1.87

inhibition of cysteine-type endopeptidase activity involved in apoptotic process
zymogen inhibition
inhibition of cysteine-type endopeptidase activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
negative regulation of protein processing
negative regulation of protein maturation
regulation of protein processing
regulation of protein maturation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of cysteine-type endopeptidase activity
positive regulation of protein ubiquitination
positive regulation of protein modification by small protein conjugation or removal
positive regulation of canonical Wnt signaling pathway
positive regulation of Wnt signaling pathway
regulation of protein ubiquitination
regulation of cysteine-type endopeptidase activity involved in apoptotic process
ubiquitin protein ligase activity
regulation of protein modification by small protein conjugation or removal
regulation of cysteine-type endopeptidase activity
negative regulation of endopeptidase activity
negative regulation of peptidase activity
regulation of canonical Wnt signaling pathway
negative regulation of proteolysis
regulation of Wnt signaling pathway
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
protein ubiquitination
regulation of proteolysis
protein modification by small protein conjugation
negative regulation of catalytic activity
negative regulation of apoptotic process
negative regulation of programmed cell death
apoptotic process
protein modification by small protein conjugation or removal
negative regulation of cell death
negative regulation of cellular protein metabolic process
programmed cell death
cell death
negative regulation of protein metabolic process