BMS1

Entrez Summary: This gene likely encodes a ribosome assembly protein. A similar protein in yeast functions in 35S-rRNA processing, which includes a series of cleavage steps critical for formation of 40S ribosomes. Related pseudogenes exist on chromosomes 2, 9, 10, 15, 16, and 22.[provided by RefSeq, Mar 2009].
UniProt Summary: May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus. {ECO:0000250|UniProtKB:Q08965}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PU-H71 1μM R08 exp515	-1.96
TIC10 10μM R08 exp532	-1.77
Alda-1 10μM R06 exp262	1.75
GSK591 2.6μM R03 exp128	1.79
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.32

Global Fraction of Cell Lines Where Essential: 658/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	24/28
blood	26/28
bone	25/26
breast	24/33
central nervous system	55/56
cervix	3/4
colorectal	15/17
esophagus	11/13
fibroblast	1/1
gastric	14/16
kidney	14/21
liver	16/20
lung	72/75
lymphocyte	15/16
ovary	21/26
pancreas	20/24
peripheral nervous system	14/16
plasma cell	14/15
prostate	0/1
skin	22/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	16/22
urinary tract	26/29
uterus	5/5

Expression Distribution

DUF663
AARP2CN

U3 snoRNA binding
90S preribosome
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of SSU-rRNA
ribosomal small subunit biogenesis
rRNA processing
rRNA metabolic process
ribosome biogenesis
GTPase activity
ncRNA processing
GTP binding
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
ATP binding
RNA metabolic process
gene expression