BNIP3

Gene Information

Official Symbol: BNIP3
Official Name: BCL2 interacting protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 664
UniProt: Q12983
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3408
Expression level (log2 read counts): 5.62

Expression Distribution

intrinsic apoptotic signaling pathway in response to hypoxia
negative regulation of mitochondrial membrane permeability involved in apoptotic process
cellular response to cobalt ion
cardiac muscle cell apoptotic process
striated muscle cell apoptotic process
mitochondrial protein catabolic process
granzyme-mediated apoptotic signaling pathway
negative regulation of mitochondrial fusion
muscle cell apoptotic process
negative regulation of mitochondrial membrane permeability
autophagic cell death
positive regulation of necrotic cell death
negative regulation of membrane permeability
regulation of aerobic respiration
regulation of mitochondrial fusion
response to cobalt ion
mitochondrial fragmentation involved in apoptotic process
positive regulation of mitochondrial calcium ion concentration
negative regulation of mitochondrial membrane potential
negative regulation of membrane potential
positive regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
mitochondrial outer membrane permeabilization
positive regulation of mitochondrial fission
positive regulation of mitochondrial membrane permeability involved in apoptotic process
mitochondrial outer membrane permeabilization involved in programmed cell death
positive regulation of autophagy of mitochondrion
integral component of mitochondrial outer membrane
positive regulation of mitochondrial membrane permeability
response to hyperoxia
regulation of mitochondrial fission
regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of membrane permeability
mitochondrial calcium ion homeostasis
positive regulation of muscle cell apoptotic process
brown fat cell differentiation
response to increased oxygen levels
regulation of necrotic cell death
positive regulation of release of cytochrome c from mitochondria
regulation of cellular respiration