CARF

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Ammonium tetrathiomolybdate 10μM R08 exp448	-2.26
IWR1 50μM R08 exp495	-1.85
Dimethyloxaloylglycine 100μM R05 exp229	1.78
CCCP 1μM R00 exp11	1.81
NFN1 1μM R03 exp100	1.98
Isonicotinamide 500μM R03 exp129	2.01
Doxycycline 10μM R00 exp18	2.24
PFI-2 4μM R05 exp239	2.31

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of transcription from RNA polymerase II promoter in response to calcium ion
cellular response to potassium ion
response to potassium ion
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
cellular response to calcium ion
response to calcium ion
cellular response to metal ion
cellular response to inorganic substance
response to metal ion
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
response to inorganic substance
DNA-binding transcription factor activity
nucleolus
positive regulation of transcription by RNA polymerase II
DNA binding
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process