CGN

Entrez Summary: N/A
UniProt Summary: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Docosahexaenoic-acid 50μM R07 exp356	-2.34
Selumetinib 20μM R02 exp81	1.73
CCT251545 20μM R07 exp326	1.78
SGC2043 10μM R03 exp152	1.85

myosin complex
motor activity
transforming growth factor beta receptor signaling pathway
bicellular tight junction
cellular response to transforming growth factor beta stimulus
response to transforming growth factor beta
transmembrane receptor protein serine/threonine kinase signaling pathway
actin binding
cadherin binding
cellular response to growth factor stimulus
response to growth factor
cell junction
enzyme linked receptor protein signaling pathway
cellular response to endogenous stimulus
response to endogenous stimulus