CHADL

Entrez Summary: N/A
UniProt Summary: Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its cellular collagenous microenvironment. {ECO:0000269|PubMed:25451920}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

collagen fibril binding
negative regulation of collagen fibril organization
regulation of collagen fibril organization
negative regulation of extracellular matrix organization
extracellular matrix structural constituent conferring compression resistance
negative regulation of chondrocyte differentiation
negative regulation of cartilage development
regulation of extracellular matrix organization
regulation of chondrocyte differentiation
collagen binding
regulation of cartilage development
negative regulation of supramolecular fiber organization
extracellular matrix
regulation of supramolecular fiber organization
collagen-containing extracellular matrix
negative regulation of cellular component organization
negative regulation of cell differentiation
negative regulation of developmental process
negative regulation of multicellular organismal process
extracellular space
regulation of cell differentiation