CLU

Gene Information

Official Symbol: CLU
Official Name: clusterin
Aliases and Previous Symbols: N/A
Entrez ID: 1191
UniProt: P10909
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011].
UniProt Summary: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. {ECO:0000269|PubMed:11123922, ECO:0000269|PubMed:12047389, ECO:0000269|PubMed:12176985, ECO:0000269|PubMed:12551933, ECO:0000269|PubMed:12882985, ECO:0000269|PubMed:16113678, ECO:0000269|PubMed:17260971, ECO:0000269|PubMed:17407782, ECO:0000269|PubMed:17412999, ECO:0000269|PubMed:17689225, ECO:0000269|PubMed:19137541, ECO:0000269|PubMed:19535339, ECO:0000269|PubMed:19996109, ECO:0000269|PubMed:20068069, ECO:0000269|PubMed:21505792}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12802
Expression level (log2 read counts): 2.37

Expression Distribution

positive regulation of neurofibrillary tangle assembly
negative regulation of cellular response to thapsigargin
negative regulation of cellular response to tunicamycin
regulation of cellular response to tunicamycin
regulation of neuronal signal transduction
perinuclear endoplasmic reticulum lumen
regulation of cellular response to thapsigargin
chaperone-mediated protein transport involved in chaperone-mediated autophagy
chromaffin granule
immune complex clearance
regulation of neurofibrillary tangle assembly
protein targeting to lysosome involved in chaperone-mediated autophagy
positive regulation of inclusion body assembly
protein targeting to vacuole involved in autophagy
positive regulation of amyloid fibril formation
central nervous system myelin maintenance
negative regulation of amyloid fibril formation
neurofibrillary tangle
positive regulation of tau-protein kinase activity
microglial cell proliferation
macrophage proliferation
regulation of amyloid fibril formation
chaperone-mediated autophagy
spherical high-density lipoprotein particle
negative regulation of protein homooligomerization
positive regulation of protein homooligomerization
chaperone-mediated protein transport
regulation of tau-protein kinase activity
negative regulation of amyloid-beta formation
myelin maintenance
negative regulation of amyloid precursor protein catabolic process
positive regulation of amyloid-beta formation
regulation of inclusion body assembly
regulation of amyloid-beta clearance
apical dendrite
glial cell proliferation
reverse cholesterol transport
negative regulation of protein oligomerization
chaperone-mediated protein complex assembly
positive regulation of amyloid precursor protein catabolic process