COL5A1

Entrez Summary: This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].
UniProt Summary: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

integrin biosynthetic process
collagen type V trimer
negative regulation of endodermal cell differentiation
regulation of endodermal cell differentiation
tendon development
negative regulation of gastrulation
collagen biosynthetic process
wound healing, spreading of epidermal cells
platelet-derived growth factor binding
proteoglycan binding
epiboly involved in wound healing
wound healing, spreading of cells
epiboly
negative regulation of embryonic development
regulation of gastrulation
extracellular matrix structural constituent conferring tensile strength
collagen fibril organization
morphogenesis of an epithelial sheet
collagen metabolic process
basement membrane
plasma membrane organization
regulation of embryonic development
integrin binding
extracellular matrix structural constituent
eye morphogenesis
heparin binding
connective tissue development
extracellular matrix
heart morphogenesis
sensory organ morphogenesis
endoplasmic reticulum lumen
extracellular matrix organization
eye development
visual system development
collagen-containing extracellular matrix
sensory system development
skin development
extracellular structure organization
endomembrane system organization
morphogenesis of an epithelium