CRTC2

Entrez Summary: N/A
UniProt Summary: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:14536081, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:16809310, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Diepoxybutane 3μM R07 exp354	-1.86
TIC10 10μM R08 exp532	-1.77
Tunicamycin 0.04μM R07 exp418	-1.74
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.77
UM0131023 0.05μM R05 exp248	2.01

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

histone H3-K9 acetylation
cAMP response element binding protein binding
histone H3-K9 modification
positive regulation of CREB transcription factor activity
toxin transport
gluconeogenesis
hexose biosynthetic process
histone H3 acetylation
monosaccharide biosynthetic process
protein homotetramerization
histone acetylation
glucose metabolic process
internal peptidyl-lysine acetylation
peptidyl-lysine acetylation
internal protein amino acid acetylation
carbohydrate biosynthetic process
protein acetylation
protein tetramerization
hexose metabolic process
glucose homeostasis
carbohydrate homeostasis
protein acylation
monosaccharide metabolic process
positive regulation of DNA-binding transcription factor activity
peptidyl-lysine modification
protein homooligomerization
histone modification
covalent chromatin modification
chromatin binding
regulation of DNA-binding transcription factor activity
carbohydrate metabolic process
protein complex oligomerization
small molecule biosynthetic process
chromatin organization
viral process
symbiotic process
interspecies interaction between organisms
peptidyl-amino acid modification
chromosome organization
chemical homeostasis