CSGALNACT1

Gene Information

Official Symbol: CSGALNACT1
Official Name: chondroitin sulfate N-acetylgalactosaminyltransferase 1
Aliases and Previous Symbols: N/A
Entrez ID: 55790
UniProt: Q8TDX6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan (By similarity). {ECO:0000250|UniProtKB:Q8BJQ9, ECO:0000269|PubMed:11788602, ECO:0000269|PubMed:12163485, ECO:0000269|PubMed:12446672, ECO:0000269|PubMed:17145758, ECO:0000269|PubMed:21160489, ECO:0000269|PubMed:27599773}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8683
Expression level (log2 read counts): 0.53

Expression Distribution

peptidoglycan glycosyltransferase activity
chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
UDP-N-acetylgalactosamine metabolic process
UDP-glucuronate metabolic process
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity
heparin biosynthetic process
heparin metabolic process
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
dermatan sulfate proteoglycan biosynthetic process
dermatan sulfate proteoglycan metabolic process
acetylgalactosaminyltransferase activity
chondroitin sulfate biosynthetic process
endochondral ossification
glucuronosyltransferase activity
replacement ossification
heparan sulfate proteoglycan biosynthetic process
chondroitin sulfate proteoglycan biosynthetic process
heparan sulfate proteoglycan metabolic process
nucleotide-sugar metabolic process
chondroitin sulfate metabolic process
amino sugar metabolic process
cellular polysaccharide biosynthetic process
chondroitin sulfate proteoglycan metabolic process
polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
integral component of Golgi membrane
proteoglycan biosynthetic process
endochondral bone morphogenesis
cellular polysaccharide metabolic process
polysaccharide metabolic process
Golgi cisterna membrane
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
mucopolysaccharide metabolic process
aminoglycan biosynthetic process
bone morphogenesis
carbohydrate biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process