DCN

Gene Information

Official Symbol: DCN
Official Name: decorin
Aliases and Previous Symbols: N/A
Entrez ID: 1634
UniProt: P07585
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015].
UniProt Summary: May affect the rate of fibrils formation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13818
Expression level (log2 read counts): 1.96

Expression Distribution

Screen	Score
UM0011500 10μM R05 exp246	-1.92
VHL-ligand-1 20μM R07 exp421	-1.87
Dexamethasone 0.006μM R07 exp351	-1.85
CR131-b 0.005μM R08 exp474	1.91

LRR 4
LRRNT

collagen type VI trimer
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of cellular response to vascular endothelial growth factor stimulus
positive regulation of mitochondrial depolarization
dermatan sulfate biosynthetic process
positive regulation of membrane depolarization
dermatan sulfate metabolic process
chondroitin sulfate catabolic process
positive regulation of mitochondrial fission
dermatan sulfate proteoglycan biosynthetic process
extracellular matrix structural constituent conferring compression resistance
dermatan sulfate proteoglycan metabolic process
regulation of vascular endothelial growth factor signaling pathway
regulation of cellular response to vascular endothelial growth factor stimulus
regulation of mitochondrial depolarization
regulation of mitochondrial fission
glycosaminoglycan binding
chondroitin sulfate biosynthetic process
extracellular matrix binding
chondroitin sulfate proteoglycan biosynthetic process
chondroitin sulfate metabolic process
regulation of membrane depolarization
chondroitin sulfate proteoglycan metabolic process
negative regulation of endothelial cell migration
sulfur compound catabolic process
peptide cross-linking
glycosaminoglycan catabolic process
collagen binding
negative regulation of epithelial cell migration
aminoglycan catabolic process
proteoglycan biosynthetic process
positive regulation of macroautophagy
regulation of mitochondrial membrane potential
positive regulation of phosphatidylinositol 3-kinase signaling
proteoglycan metabolic process
lysosomal lumen
Golgi lumen
negative regulation of angiogenesis
glycosaminoglycan biosynthetic process