DET1

Entrez Summary: N/A
UniProt Summary: Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. {ECO:0000269|PubMed:14739464}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Prochlorperazine 5.2μM R02 exp77	1.71
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	1.9
Celastrol 0.12μM R05 exp225	2.3
Selumetinib 20μM R02 exp81	2.58
I-BRD9 4μM R07 exp365	2.58

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	2/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	2/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	2/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein binding, bridging involved in substrate recognition for ubiquitination
Cul4A-RING E3 ubiquitin ligase complex
Cul4-RING E3 ubiquitin ligase complex
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of cellular protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
positive regulation of protein catabolic process
regulation of cellular protein catabolic process
protein-containing complex binding
ubiquitin protein ligase binding
positive regulation of proteolysis
positive regulation of cellular catabolic process
regulation of protein catabolic process
positive regulation of catabolic process
protein ubiquitination
regulation of proteolysis
protein modification by small protein conjugation
regulation of cellular catabolic process
protein modification by small protein conjugation or removal
regulation of catabolic process
protein-containing complex assembly
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
protein-containing complex subunit organization