DLC1
Gene Information
- Official Symbol: DLC1
- Official Name: DLC1 Rho GTPase activating protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 10395
- UniProt: Q96QB1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RhoGAP |
| START |
| SAM 2 |
GO Terms
| positive regulation of execution phase of apoptosis |
| negative regulation of focal adhesion assembly |
| negative regulation of stress fiber assembly |
| negative regulation of adherens junction organization |
| negative regulation of Rho protein signal transduction |
| negative regulation of cell junction assembly |
| negative regulation of actin filament bundle assembly |
| focal adhesion assembly |
| cell-substrate adherens junction assembly |
| adherens junction assembly |
| SH2 domain binding |
| negative regulation of cell-matrix adhesion |
| hindbrain morphogenesis |
| regulation of execution phase of apoptosis |
| cell-substrate junction assembly |
| positive regulation of protein dephosphorylation |
| negative regulation of Ras protein signal transduction |
| cortical actin cytoskeleton |
| positive regulation of dephosphorylation |
| negative regulation of small GTPase mediated signal transduction |
| regulation of cell-substrate junction assembly |
| regulation of focal adhesion assembly |
| negative regulation of cell-substrate adhesion |
| regulation of adherens junction organization |
| caveola |
| regulation of stress fiber assembly |
| adherens junction organization |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of actomyosin structure organization |
| regulation of cell junction assembly |
| neural tube closure |
| tube closure |
| regulation of actin filament bundle assembly |
| ruffle membrane |
| primary neural tube formation |
| neural tube formation |
| regulation of cell-matrix adhesion |
| embryonic epithelial tube formation |
| cell-matrix adhesion |
| negative regulation of supramolecular fiber organization |
| epithelial tube formation |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of cytoskeleton organization |
| regulation of protein dephosphorylation |
| regulation of Rho protein signal transduction |
| morphogenesis of embryonic epithelium |
| tube formation |
| hindbrain development |
| positive regulation of cysteine-type endopeptidase activity |
| regulation of cell shape |
| lipid binding |
| neural tube development |
| cell junction assembly |
| positive regulation of endopeptidase activity |
| cell-substrate adhesion |
| positive regulation of peptidase activity |
| regulation of cell-substrate adhesion |
| regulation of dephosphorylation |
| cell junction organization |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of cysteine-type endopeptidase activity |
| regulation of Ras protein signal transduction |
| heart morphogenesis |
| negative regulation of cell migration |
| regulation of actin filament organization |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| GTPase activator activity |
| epithelial tube morphogenesis |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| regulation of actin cytoskeleton organization |
| regulation of small GTPase mediated signal transduction |
| regulation of supramolecular fiber organization |
| positive regulation of proteolysis |
| negative regulation of organelle organization |
| forebrain development |
| regulation of actin filament-based process |
| positive regulation of GTPase activity |
| focal adhesion |
| regulation of endopeptidase activity |
| morphogenesis of an epithelium |
| regulation of peptidase activity |
| regulation of GTPase activity |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| negative regulation of intracellular signal transduction |
| heart development |
| regulation of cytoskeleton organization |
| tissue morphogenesis |
| embryonic morphogenesis |
| actin filament-based process |
| chordate embryonic development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| regulation of proteolysis |
| brain development |
| positive regulation of hydrolase activity |
| head development |
| tube development |
| regulation of cell migration |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| apoptotic process |
| cell adhesion |
| biological adhesion |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| programmed cell death |
| regulation of anatomical structure morphogenesis |
| cell death |
| cytoskeleton organization |
| epithelium development |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of cell death |
| positive regulation of protein metabolic process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319 | -1.8 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.538 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15992
- Expression level (log2 read counts): 0.37
Expression Distribution
DLC1 Expression in NALM6 Cells: 0.37
