DPYD

Entrez Summary: The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Dus
DHO dh

dihydropyrimidine dehydrogenase (NADP+) activity
pyrimidine deoxyribonucleoside catabolic process
thymidine catabolic process
beta-alanine biosynthetic process
uracil catabolic process
uracil binding
thymine catabolic process
thymine metabolic process
uracil metabolic process
deoxyribonucleoside catabolic process
purine nucleobase catabolic process
beta-alanine metabolic process
thymidine metabolic process
pyrimidine deoxyribonucleoside metabolic process
iron-sulfur cluster binding
pyrimidine nucleobase catabolic process
deoxyribonucleoside metabolic process
nucleobase catabolic process
purine nucleobase metabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
nucleoside catabolic process
pyrimidine nucleoside metabolic process
NADP binding
4 iron, 4 sulfur cluster binding
nucleobase metabolic process
neurotransmitter biosynthetic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
purine-containing compound catabolic process
flavin adenine dinucleotide binding
cellular amino acid biosynthetic process
neurotransmitter metabolic process
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
drug catabolic process
carbohydrate derivative catabolic process
carboxylic acid biosynthetic process