ELOVL6

Gene Information

Official Symbol: ELOVL6
Official Name: ELOVL fatty acid elongase 6
Aliases and Previous Symbols: N/A
Entrez ID: 79071
UniProt: Q9H5J4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP- Rule:MF_03206, ECO:0000269|PubMed:20937905}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15883
Expression level (log2 read counts): 6.59

Expression Distribution

Screen	Score
Q15 2.7μM R02 exp79	2.11
UM0125461 0.74μM R02 exp84	3.96

fatty acid elongation, monounsaturated fatty acid
fatty acid elongation, saturated fatty acid
3-oxo-arachidoyl-CoA synthase activity
very-long-chain 3-ketoacyl-CoA synthase activity
fatty acid elongation, polyunsaturated fatty acid
3-oxo-cerotoyl-CoA synthase activity
fatty acid elongation, unsaturated fatty acid
3-oxo-lignoceronyl-CoA synthase activity
fatty acid elongase activity
very long-chain fatty acid biosynthetic process
fatty acid elongation
long-chain fatty-acyl-CoA biosynthetic process
long-chain fatty-acyl-CoA metabolic process
very long-chain fatty acid metabolic process
long-chain fatty acid biosynthetic process
fatty-acyl-CoA biosynthetic process
fatty-acyl-CoA metabolic process
regulation of cholesterol biosynthetic process
unsaturated fatty acid biosynthetic process
regulation of sterol biosynthetic process
thioester biosynthetic process
acyl-CoA biosynthetic process
regulation of cholesterol metabolic process
nucleoside bisphosphate biosynthetic process
purine nucleoside bisphosphate biosynthetic process
ribonucleoside bisphosphate biosynthetic process
regulation of alcohol biosynthetic process
regulation of steroid biosynthetic process
sphingolipid biosynthetic process
fatty acid derivative biosynthetic process
acyl-CoA metabolic process
thioester metabolic process
positive regulation of cold-induced thermogenesis
integral component of endoplasmic reticulum membrane
unsaturated fatty acid metabolic process
regulation of steroid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
membrane lipid biosynthetic process
ribonucleoside bisphosphate metabolic process