EML2

Entrez Summary: N/A
UniProt Summary: Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules. {ECO:0000269|PubMed:11694528}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Torin1 0.08μM R02 exp82	-1.72
Pterostilbene 16μM R02 exp78	1.83

regulation of microtubule nucleation
negative regulation of microtubule polymerization
microtubule associated complex
negative regulation of microtubule polymerization or depolymerization
regulation of microtubule polymerization
tubulin binding
negative regulation of protein polymerization
mitotic spindle
regulation of microtubule polymerization or depolymerization
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
negative regulation of cytoskeleton organization
sensory perception of sound
sensory perception of mechanical stimulus
regulation of microtubule cytoskeleton organization
protein C-terminus binding
visual perception
regulation of microtubule-based process
regulation of protein polymerization
sensory perception of light stimulus
microtubule binding
microtubule
signaling receptor binding
regulation of supramolecular fiber organization
negative regulation of organelle organization
regulation of protein complex assembly
regulation of cytoskeleton organization
negative regulation of cellular component organization
regulation of cellular component biogenesis
sensory perception
regulation of organelle organization
nervous system process
system process