ENAM

Entrez Summary: Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009].
UniProt Summary: Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. {ECO:0000250|UniProtKB:O97939}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ameloblast differentiation
positive regulation of enamel mineralization
positive regulation of odontogenesis of dentin-containing tooth
regulation of enamel mineralization
positive regulation of tooth mineralization
structural constituent of tooth enamel
regulation of tooth mineralization
positive regulation of odontogenesis
regulation of odontogenesis of dentin-containing tooth
amelogenesis
regulation of odontogenesis
positive regulation of biomineral tissue development
positive regulation of biomineralization
positive regulation of animal organ morphogenesis
odontogenesis of dentin-containing tooth
biomineralization
biomineral tissue development
regulation of biomineralization
regulation of biomineral tissue development
columnar/cuboidal epithelial cell differentiation
odontogenesis
extracellular matrix
regulation of animal organ morphogenesis
endoplasmic reticulum lumen
post-translational protein modification
regulation of cell morphogenesis
epithelial cell differentiation
anatomical structure formation involved in morphogenesis
animal organ morphogenesis
regulation of anatomical structure morphogenesis
epithelium development
positive regulation of developmental process
positive regulation of multicellular organismal process
tissue development