EXOC1

Entrez Summary: N/A
UniProt Summary: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	1/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	2/75
lymphocyte	0/16
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

Screen	Score
UM0011500 10μM R05 exp246	1.76
Bleomycin 5μM R08 exp459	1.93

cytoplasmic side of apical plasma membrane
exocyst localization
exocyst
GTP-Rho binding
cellular protein-containing complex localization
Flemming body
Golgi to plasma membrane transport
phosphatidylinositol-mediated signaling
inositol lipid-mediated signaling
phosphatidylinositol-4,5-bisphosphate binding
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
regulation of macroautophagy
defense response to virus
protein-containing complex localization
positive regulation of protein secretion
response to virus
positive regulation of peptide secretion
regulation of autophagy
Golgi vesicle transport
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion
perinuclear region of cytoplasm
viral process
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
symbiotic process
exocytosis
regulation of secretion
interspecies interaction between organisms
regulation of cellular catabolic process
defense response to other organism
positive regulation of transport
regulation of catabolic process