EYA3

Entrez Summary: N/A
UniProt Summary: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
I-BRD9 4μM R07 exp365	1.71
Thapsigargin 0.005μM R07 exp407	2.08

histone dephosphorylation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of signal transduction in absence of ligand
regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of DNA repair
positive regulation of response to DNA damage stimulus
protein tyrosine phosphatase activity
negative regulation of extrinsic apoptotic signaling pathway
peptidyl-tyrosine dephosphorylation
regulation of DNA repair
response to ionizing radiation
regulation of extrinsic apoptotic signaling pathway
double-strand break repair
positive regulation of DNA metabolic process
transcription factor complex
protein dephosphorylation
regulation of response to DNA damage stimulus
visual perception
sensory perception of light stimulus
negative regulation of apoptotic signaling pathway
dephosphorylation
regulation of DNA metabolic process
histone modification
covalent chromatin modification
regulation of apoptotic signaling pathway
response to radiation
centrosome
DNA repair
chromatin organization
regulation of cellular response to stress
DNA metabolic process
cellular response to DNA damage stimulus
negative regulation of apoptotic process
negative regulation of programmed cell death
sensory perception
negative regulation of cell death
chromosome organization
response to abiotic stimulus
negative regulation of signal transduction
negative regulation of cell communication