F2RL3

Gene Information

Official Symbol: F2RL3
Official Name: F2R like thrombin or trypsin receptor 3
Aliases and Previous Symbols: N/A
Entrez ID: 9002
UniProt: Q96RI0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016].
UniProt Summary: Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation. {ECO:0000269|PubMed:10079109}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18901
Expression level (log2 read counts): 6.62

Expression Distribution

Gene	Correlation
POLR2J3	0.414
HGC6.3	0.4

thrombin-activated receptor activity
platelet dense granule organization
thrombin-activated receptor signaling pathway
positive regulation of Rho protein signal transduction
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
secretory granule organization
positive regulation of release of sequestered calcium ion into cytosol
positive regulation of calcium ion transport into cytosol
positive regulation of Ras protein signal transduction
positive regulation of calcium ion transmembrane transport
positive regulation of small GTPase mediated signal transduction
regulation of release of sequestered calcium ion into cytosol
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of calcium ion transport into cytosol
positive regulation of calcium ion transport
regulation of sequestering of calcium ion
platelet activation
positive regulation of cation transmembrane transport
regulation of Rho protein signal transduction
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
positive regulation of transmembrane transport
regulation of Ras protein signal transduction
regulation of calcium ion transport
positive regulation of ion transport
positive regulation of cytosolic calcium ion concentration
blood coagulation
coagulation
hemostasis
vesicle organization
regulation of cytosolic calcium ion concentration
regulation of cation transmembrane transport
regulation of small GTPase mediated signal transduction
regulation of metal ion transport
endomembrane system organization
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
regulation of ion transmembrane transport
wound healing