GABRR2
Gene Information
- Official Symbol: GABRR2
- Official Name: gamma-aminobutyric acid type A receptor subunit rho2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2570
- UniProt: P28476
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability. [provided by RefSeq, Apr 2016].
- UniProt Summary: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 3015
- Expression level (log2 read counts): 0.58
GABRR2 Expression in NALM6 Cells: 0.58
