GH2

Gene Information

Official Symbol: GH2
Official Name: growth hormone 2
Aliases and Previous Symbols: N/A
Entrez ID: 2689
UniProt: P01242
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16678
Expression level (log2 read counts): -3.9

Expression Distribution

growth hormone receptor binding
growth hormone receptor signaling pathway via JAK-STAT
endosome lumen
growth hormone receptor signaling pathway
cellular response to growth hormone stimulus
response to growth hormone
positive regulation of tyrosine phosphorylation of STAT protein
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
hormone activity
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
growth factor activity
positive regulation of peptidyl-tyrosine phosphorylation
regulation of peptidyl-tyrosine phosphorylation
positive regulation of growth
cellular response to peptide hormone stimulus
cellular response to peptide
response to peptide hormone
response to peptide
response to nutrient levels
transmembrane receptor protein tyrosine kinase signaling pathway
response to extracellular stimulus
cellular response to organonitrogen compound
cellular response to hormone stimulus
cellular response to nitrogen compound
regulation of growth
enzyme linked receptor protein signaling pathway
response to hormone
response to organonitrogen compound
positive regulation of protein phosphorylation
cellular response to oxygen-containing compound
positive regulation of phosphorylation
response to nitrogen compound
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
cellular response to endogenous stimulus
positive regulation of protein modification process
regulation of protein phosphorylation