GLRA2

Entrez Summary: The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010].
UniProt Summary: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467). {ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:2155780, ECO:0000269|PubMed:23895467, ECO:0000269|PubMed:25445488}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Neur chan memb
Neur chan LBD

glycine-gated chloride ion channel activity
extracellularly glycine-gated chloride channel activity
glycinergic synapse
synaptic transmission, glycinergic
cellular response to ethanol
glycine binding
cellular response to zinc ion
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
chloride channel complex
extracellular ligand-gated ion channel activity
response to zinc ion
chloride channel activity
excitatory postsynaptic potential
chemical synaptic transmission, postsynaptic
cellular response to amino acid stimulus
cellular response to alcohol
chloride transmembrane transport
regulation of postsynaptic membrane potential
chloride transport
neuropeptide signaling pathway
inorganic anion transmembrane transport
response to amino acid
cellular response to antibiotic
response to ethanol
transmembrane signaling receptor activity
inorganic anion transport
cellular response to metal ion
postsynaptic membrane
cellular response to acid chemical
cellular response to toxic substance
cellular response to inorganic substance
response to alcohol
synapse
anion transmembrane transport
response to antibiotic
neuron projection
response to acid chemical
response to metal ion
cellular response to drug
chemical synaptic transmission