GMDS

Entrez Summary: N/A
UniProt Summary: Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RmlD sub bind
Epimerase

GDP-mannose 4,6-dehydratase activity
de novo GDP-L-fucose biosynthetic process
NADP+ binding
GDP-L-fucose biosynthetic process
GDP-L-fucose metabolic process
GDP-mannose metabolic process
nucleotide-sugar biosynthetic process
nucleotide-sugar metabolic process
Notch signaling pathway
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
carbohydrate derivative metabolic process
identical protein binding
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
small molecule metabolic process