GTF2H2

Gene Information

Official Symbol: GTF2H2
Official Name: general transcription factor IIH subunit 2
Aliases and Previous Symbols: N/A
Entrez ID: 2966
UniProt: Q13888
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre- initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. {ECO:0000269|PubMed:11319235, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:8194529, ECO:0000269|PubMed:9852112}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2147
Expression level (log2 read counts): 6.83

Expression Distribution

C1 4
Ssl1

positive regulation of DNA helicase activity
positive regulation of DNA duplex unwinding
core TFIIH complex portion of holo TFIIH complex
regulation of DNA helicase activity
regulation of DNA duplex unwinding
positive regulation of helicase activity
transcription factor TFIIH core complex
transcription factor TFIIH holo complex
regulation of helicase activity
G protein-coupled receptor internalization
RNA polymerase II general transcription initiation factor activity
RNA polymerase II CTD heptapeptide repeat kinase activity
negative adaptation of signaling pathway
desensitization of G protein-coupled receptor signaling pathway
adaptation of signaling pathway
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, DNA incision, 3-to lesion
nucleotide-excision repair, DNA duplex unwinding
global genome nucleotide-excision repair
transcription elongation from RNA polymerase I promoter
nucleotide-excision repair, preincision complex assembly
termination of RNA polymerase I transcription
7-methylguanosine mRNA capping
7-methylguanosine RNA capping
RNA capping
transcription initiation from RNA polymerase I promoter
nucleotide-excision repair, DNA incision, 5-to lesion
transcription factor TFIID complex
transcription by RNA polymerase I
nucleotide-excision repair, DNA incision
DNA-dependent ATPase activity
negative regulation of G protein-coupled receptor signaling pathway
positive regulation of ATPase activity
receptor internalization
DNA-templated transcription, termination
transcription-coupled nucleotide-excision repair
transcription elongation from RNA polymerase II promoter
regulation of ATPase activity
DNA-templated transcription, elongation
receptor metabolic process