HAAO

Entrez Summary: N/A
UniProt Summary: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. {ECO:0000255|HAMAP- Rule:MF_03019, ECO:0000269|PubMed:7514594}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

3-HAO
Cupin 2

3-hydroxyanthranilate 3,4-dioxygenase activity
quinolinate biosynthetic process
anthranilate metabolic process
quinolinate metabolic process
de novo NAD biosynthetic process from tryptophan
de novo NAD biosynthetic process
tryptophan catabolic process
indole-containing compound catabolic process
indolalkylamine catabolic process
tryptophan metabolic process
dicarboxylic acid biosynthetic process
indolalkylamine metabolic process
cellular biogenic amine catabolic process
amine catabolic process
indole-containing compound metabolic process
ferrous iron binding
benzene-containing compound metabolic process
aromatic amino acid family catabolic process
NAD biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
nicotinamide nucleotide metabolic process
pyridine nucleotide metabolic process
neuron cellular homeostasis
pyridine-containing compound biosynthetic process
aromatic amino acid family metabolic process
pyridine-containing compound metabolic process
oxidoreduction coenzyme metabolic process
response to zinc ion
cellular biogenic amine metabolic process
cellular amine metabolic process
response to cadmium ion
amine metabolic process
electron transfer activity
water-soluble vitamin metabolic process
dicarboxylic acid metabolic process
alpha-amino acid catabolic process
vitamin metabolic process
cellular amino acid catabolic process
coenzyme biosynthetic process