HIST1H1A

Entrez Summary: N/A
UniProt Summary: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nucleosome positioning
negative regulation of chromatin silencing
nuclear euchromatin
negative regulation of gene silencing
regulation of chromatin silencing
chromosome condensation
nucleosomal DNA binding
negative regulation of DNA recombination
positive regulation of receptor-mediated endocytosis
negative regulation of chromatin organization
positive regulation of gene expression, epigenetic
nucleosome
chromatin DNA binding
regulation of receptor-mediated endocytosis
positive regulation of endocytosis
double-stranded DNA binding
regulation of DNA recombination
nucleosome assembly
negative regulation of DNA metabolic process
regulation of gene silencing
chromatin assembly
negative regulation of chromosome organization
vesicle
chromatin assembly or disassembly
nucleosome organization
heparin binding
DNA packaging
regulation of chromatin organization
protein-DNA complex assembly
regulation of endocytosis
regulation of gene expression, epigenetic
nuclear chromatin
protein-DNA complex subunit organization
DNA conformation change
regulation of chromosome organization
regulation of DNA metabolic process
negative regulation of organelle organization
spermatogenesis
regulation of vesicle-mediated transport
male gamete generation