HIST1H2BJ

Entrez Summary: N/A
UniProt Summary: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 638/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	23/28
blood	27/28
bone	21/26
breast	29/33
central nervous system	48/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	12/16
kidney	18/21
liver	17/20
lung	69/75
lymphocyte	10/16
ovary	25/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	15/15
prostate	1/1
skin	18/24
soft tissue	6/9
thyroid	1/2
upper aerodigestive	20/22
urinary tract	26/29
uterus	2/5

Expression Distribution

Histone
CBFD NFYB HMF

innate immune response in mucosa
negative regulation of tumor necrosis factor-mediated signaling pathway
mucosal immune response
organ or tissue specific immune response
lipopolysaccharide binding
antibacterial humoral response
disruption of cells of other organism
killing of cells of other organism
regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of cytokine-mediated signaling pathway
antimicrobial humoral immune response mediated by antimicrobial peptide
negative regulation of response to cytokine stimulus
nucleosome
defense response to Gram-negative bacterium
cell killing
defense response to Gram-positive bacterium
antimicrobial humoral response
nucleosome assembly
chromatin assembly
modification of morphology or physiology of other organism
chromatin assembly or disassembly
nucleosome organization
regulation of cytokine-mediated signaling pathway
regulation of response to cytokine stimulus
DNA packaging
protein-DNA complex assembly
protein-DNA complex subunit organization
DNA conformation change
defense response to bacterium
humoral immune response
protein heterodimerization activity
protein ubiquitination
response to bacterium
chromatin organization
innate immune response
protein modification by small protein conjugation
interspecies interaction between organisms
cellular protein-containing complex assembly
defense response to other organism
protein modification by small protein conjugation or removal