HOXB7

Gene Information

Official Symbol: HOXB7
Official Name: homeobox B7
Aliases and Previous Symbols: N/A
Entrez ID: 3217
UniProt: P09629
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5612
Expression level (log2 read counts): -0.71

Expression Distribution

Screen	Score
Monensin 0.3μM R08 exp507	1.7
Golgicide-A 2μM R03 exp121	1.95

positive regulation of branching involved in ureteric bud morphogenesis
positive regulation of mesonephros development
regulation of branching involved in ureteric bud morphogenesis
regulation of mesonephros development
positive regulation of morphogenesis of an epithelium
positive regulation of kidney development
regulation of kidney development
regulation of morphogenesis of a branching structure
positive regulation of animal organ morphogenesis
embryonic skeletal system morphogenesis
RNA polymerase II distal enhancer sequence-specific DNA binding
embryonic skeletal system development
regulation of morphogenesis of an epithelium
anterior/posterior pattern specification
myeloid cell differentiation
skeletal system morphogenesis
regulation of animal organ morphogenesis
nuclear body
embryonic organ morphogenesis
regionalization
embryonic organ development
pattern specification process
DNA-binding transcription activator activity, RNA polymerase II-specific
skeletal system development
RNA polymerase II proximal promoter sequence-specific DNA binding
hemopoiesis
embryonic morphogenesis
hematopoietic or lymphoid organ development
chordate embryonic development
immune system development
embryo development ending in birth or egg hatching
DNA-binding transcription factor activity
animal organ morphogenesis
embryo development
regulation of anatomical structure morphogenesis
positive regulation of transcription by RNA polymerase II
positive regulation of developmental process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription