HSD17B11

Entrez Summary: N/A
UniProt Summary: Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
LJH685 5μM R02 exp73	1.77
Citral 50μM R06 exp274	1.79

KR
adh short

androgen catabolic process
steroid dehydrogenase activity
estradiol 17-beta-dehydrogenase activity
estrogen biosynthetic process
hormone catabolic process
steroid catabolic process
androgen metabolic process
estrogen metabolic process
steroid hormone biosynthetic process
hormone biosynthetic process
lipid droplet
cellular hormone metabolic process
steroid biosynthetic process
hormone metabolic process
steroid metabolic process
lipid catabolic process
organic cyclic compound catabolic process
regulation of hormone levels
lipid biosynthetic process
oxidation-reduction process
lipid metabolic process
organic cyclic compound biosynthetic process
organic substance catabolic process
extracellular region