IRG1

Gene Information

Official Symbol: ACOD1
Official Name: aconitate decarboxylase 1
Aliases and Previous Symbols: N/A
Entrez ID: 730249
UniProt: A6NK06
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1- mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation. {ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15447
Expression level (log2 read counts): -6.6

Expression Distribution

aconitate decarboxylase activity
2-methylcitrate dehydratase activity
propionate metabolic process, methylcitrate cycle
tolerance induction to lipopolysaccharide
cellular response to progesterone stimulus
positive regulation of antimicrobial humoral response
propionate metabolic process
negative regulation of toll-like receptor 2 signaling pathway
regulation of antimicrobial humoral response
negative regulation of toll-like receptor 4 signaling pathway
regulation of toll-like receptor 2 signaling pathway
tolerance induction
negative regulation of lipopolysaccharide-mediated signaling pathway
positive regulation of humoral immune response
short-chain fatty acid metabolic process
cellular response to interferon-beta
regulation of toll-like receptor 4 signaling pathway
regulation of lipopolysaccharide-mediated signaling pathway
response to interferon-beta
embryo implantation
negative regulation of toll-like receptor signaling pathway
response to progesterone
negative regulation of type I interferon production
negative regulation of innate immune response
regulation of toll-like receptor signaling pathway
negative regulation of NF-kappaB transcription factor activity
cellular response to ketone
negative regulation of response to biotic stimulus
positive regulation of reactive oxygen species metabolic process
antibiotic metabolic process
regulation of type I interferon production
regulation of humoral immune response
negative regulation of inflammatory response
negative regulation of immune response
negative regulation of DNA-binding transcription factor activity
cellular response to interferon-gamma
cellular response to interleukin-1
regulation of reactive oxygen species metabolic process
female pregnancy
response to interferon-gamma