JAM3

Entrez Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011].
UniProt Summary: Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN). The soluble form is a mediator of angiogenesis. {ECO:0000269|PubMed:12208882, ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:20592283}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.002μM R01 exp54	-2.15
CCT251545 0.2μM R06 exp271	-2.1
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.82
Betulinic acid 10 to 15μM on day4 R05 exp222	1.75

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of actin cytoskeleton organization by cell-cell adhesion
myeloid progenitor cell differentiation
paranodal junction
neutrophil homeostasis
Schmidt-Lanterman incisure
leukocyte migration involved in inflammatory response
cell-cell contact zone
axon regeneration
desmosome
regulation of neutrophil chemotaxis
neuron projection regeneration
regulation of neutrophil migration
regulation of granulocyte chemotaxis
response to axon injury
transmission of nerve impulse
leukocyte homeostasis
hematopoietic progenitor cell differentiation
myelination
myeloid cell homeostasis
axon ensheathment
ensheathment of neurons
regulation of leukocyte chemotaxis
establishment of cell polarity
bicellular tight junction
cell-matrix adhesion
integrin binding
multicellular organismal signaling
spermatid development
regeneration
spermatid differentiation
cell-substrate adhesion
regulation of leukocyte migration
establishment or maintenance of cell polarity
homeostasis of number of cells
regulation of chemotaxis
germ cell development
angiogenesis
extracellular matrix organization
regulation of actin cytoskeleton organization
cellular process involved in reproduction in multicellular organism