KBTBD8

Entrez Summary: N/A
UniProt Summary: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:26399832}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

neural crest formation
Cul3-RING ubiquitin ligase complex
protein monoubiquitination
epithelial to mesenchymal transition
neural crest cell development
stem cell development
mesenchymal cell development
neural crest cell differentiation
spindle
mesenchymal cell differentiation
stem cell differentiation
mesenchyme development
regulation of translation
post-translational protein modification
regulation of cellular amide metabolic process
posttranscriptional regulation of gene expression
chordate embryonic development
embryo development ending in birth or egg hatching
protein ubiquitination
protein modification by small protein conjugation
anatomical structure formation involved in morphogenesis
embryo development
Golgi apparatus
protein modification by small protein conjugation or removal
cell development
tissue development