KCNE2

Gene Information

Official Symbol: KCNE2
Official Name: potassium voltage-gated channel subfamily E regulatory subunit 2
Aliases and Previous Symbols: N/A
Entrez ID: 9992
UniProt: Q9Y6J6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008].
UniProt Summary: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). {ECO:0000250|UniProtKB:P63161, ECO:0000269|PubMed:10219239, ECO:0000269|PubMed:11101505}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7679
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
OICR-9429 10μM R03 exp142	-1.74
Temozolomide 200μM R04 exp189	1.87
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	1.96

regulation of cyclic nucleotide-gated ion channel activity
regulation of inward rectifier potassium channel activity
negative regulation of delayed rectifier potassium channel activity
ventricular cardiac muscle cell membrane repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
negative regulation of voltage-gated potassium channel activity
positive regulation of voltage-gated calcium channel activity
membrane repolarization during ventricular cardiac muscle cell action potential
potassium ion export across plasma membrane
membrane repolarization during cardiac muscle cell action potential
membrane repolarization during action potential
regulation of delayed rectifier potassium channel activity
cardiac muscle cell membrane repolarization
negative regulation of potassium ion transmembrane transporter activity
tongue development
inward rectifier potassium channel activity
ventricular cardiac muscle cell action potential
membrane repolarization
regulation of ventricular cardiac muscle cell membrane repolarization
negative regulation of potassium ion transmembrane transport
regulation of cardiac muscle cell membrane repolarization
negative regulation of potassium ion transport
delayed rectifier potassium channel activity
regulation of membrane repolarization
regulation of voltage-gated calcium channel activity
regulation of heart rate by cardiac conduction
positive regulation of calcium ion transmembrane transporter activity
cardiac muscle cell action potential involved in contraction
export across plasma membrane
potassium channel regulator activity
cardiac muscle cell contraction
negative regulation of cation channel activity
potassium ion import across plasma membrane
cardiac muscle cell action potential
regulation of potassium ion transmembrane transporter activity
positive regulation of cation channel activity
positive regulation of calcium ion transmembrane transport
negative regulation of ion transmembrane transporter activity
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane